Oxymetazoline comes as a solution (liquid) to spray into the nose. It is usually used every 10 to 12 hours as needed, but not more often than twice in a 24-hour period. Follow the directions on the package label or on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Use oxymetazoline nasal spray exactly as directed. Do not use more or less of it or use it more often than prescribed by your doctor or directed on the label.